Association between β-lactam exposure and clearance of bacteraemia and acute kidney injury in patients with methicillin-resistant Staphylococcus aureus bloodstream infections—a post hoc analysis of the CAMERA2 trial

Abstract

Objectives In the Combination Antibiotic Therapy for Methicillin-Resistant Staphylococcus aureus (CAMERA2) trial, combination of vancomycin and 7 days of a β-lactam resulted in faster clearance of methicillin-resistant Staphylococcus aureus bacteraemia and higher rates of nephrotoxicity compared with monotherapy. Many participants received empirical β-lactam prior to enrolment. Whether the duration of β-lactam use, including the empiric treatment, impacts clinical and microbiological outcomes is unclear. Methods In a post hoc analysis of the CAMERA2 study, we investigated the impact of β-lactam therapy duration on the hazard ratio for clearance of bacteraemia and the odds ratio (OR) for deve..